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Clin Nephrol. 1995 Feb;43(2):104-9.

Use of urine albumin measurement as a replacement for total protein.

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  • 1Department of Clinical Biochemistry, London Hospital Medical College, England, UK.


We have investigated the replacement of urine total protein estimations for the assessment of glomerular permeability, by the measurement of urine albumin excretion using a latex particle enhanced immunoturbidimetric assay. An initial screen was performed using Albustix to assess the sample pre-dilution necessary for immunoanalysis. A total of 167 24-hour urine samples were analysed and urine albumin concentration correlated well with that of urine total protein (r = 0.93) over the range 0-16,800 mg/l. This protocol provides a more cost effective and analytically valid assessment of glomerular permeability.

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