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Mod Pathol. 1995 Jan;8(1):1-4.

Paget's disease of the nipple and angiosarcoma of the breast following excision and radiation therapy for carcinoma of the breast.

Author information

  • 1Department of Pathology, Deaconess Hospital, Boston, Massachusetts, USA.

Abstract

We report a case of bilateral angiosarcomas developing in breasts after radiation therapy. The angiosarcomas developed 7 years after the first dose and 3 years after the last dose of radiation. In addition, Paget's disease of the nipple was diagnosed in the right breast. c-neu overexpression was noted in the adenocarcinoma but not in the angiosarcoma. Neither tumor was immunoreactive for c-k-ras. The oncogenic expression of the radiation-induced angiosarcoma was different from that of the radiation-resistant adenocarcinoma. The simultaneous occurrence of angiosarcoma and Paget's disease of the nipple has not been reported previously. The importance of recognizing Paget's disease in post-irradiated breasts and complications of breast conservation therapy are stressed.

PMID:
7731933
[PubMed - indexed for MEDLINE]
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