Diabetes Care. 1995 Feb;18(2):245-50.

The use of areas under curves in diabetes research.

Allison DB, Paultre F, Maggio C, Mezzitis N, Pi-Sunyer FX.

Source

Obesity Research Center, St. Luke's/Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA.

Abstract

Recently, several articles appearing in the diabetes literature have suggested that many investigators are unclear about a number of issues involving the use of areas under the curve (AUCs). This prompted us to reconsider issues in the calculation, use, meaning, and presentation of AUCs. We discuss five issues: 1) What is a curve and an area? 2) How should one graphically present a group's curve? 3) How should one calculate AUCs? 4) Should one subtract baseline values from outcome values before calculating AUCs? And 5) are AUCs the best way to combine multiple readings into a single index?

PMID:: 7729306; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Blood Glucose

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Dichotomous responses of inter and postprandial hyperglycaemia to short-term calorie restriction in patients with type 2 diabetes. [Eur J Clin Invest. 2005]
Dichotomous responses of inter and postprandial hyperglycaemia to short-term calorie restriction in patients with type 2 diabetes.
Colette C, Ginet C, Boegner C, Benichou M, Pham TC, Cristol JP, Monnier L. Eur J Clin Invest. 2005 Apr; 35(4):259-64.
Review Research use of the AIDA www.2aida.org diabetes software simulation program: a review--part 2. Generating simulated blood glucose data for prototype validation. [Diabetes Technol Ther. 2003]
Review Research use of the AIDA www.2aida.org diabetes software simulation program: a review--part 2. Generating simulated blood glucose data for prototype validation.
Lehmann ED. Diabetes Technol Ther. 2003; 5(4):641-51.
Controlled portions of presweetened cereals present no glycemic penalty in persons with insulin-dependent diabetes mellitus. [J Am Diet Assoc. 1996]
Controlled portions of presweetened cereals present no glycemic penalty in persons with insulin-dependent diabetes mellitus.
Wheeler ML, Fineberg SE, Gibson R, Fineberg N. J Am Diet Assoc. 1996 May; 96(5):458-63.
Effect of blood sampling schedule and method of calculating the area under the curve on validity and precision of glycaemic index values. [Br J Nutr. 2004]
Effect of blood sampling schedule and method of calculating the area under the curve on validity and precision of glycaemic index values.
Wolever TM. Br J Nutr. 2004 Feb; 91(2):295-301.
Review Systematic reviews of the effectiveness of day care for people with severe mental disorders: (1) acute day hospital versus admission; (2) vocational rehabilitation; (3) day hospital versus outpatient care. [Health Technol Assess. 2001]
Review Systematic reviews of the effectiveness of day care for people with severe mental disorders: (1) acute day hospital versus admission; (2) vocational rehabilitation; (3) day hospital versus outpatient care.
Marshall M, Crowther R, Almaraz-Serrano A, Creed F, Sledge W, Kluiter H, Roberts C, Hill E, Wiersma D, Bond GR, et al. Health Technol Assess. 2001; 5(21):1-75.

See reviews... See all...

Cited by 14 PubMed Central articles

Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys. [Eur J Clin Nutr. 2012]
Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys.
Lee S, Kim Y, White DA, Kuk JL, Arslanian S. Eur J Clin Nutr. 2012 Dec; 66(12):1366-8. Epub 2012 Oct 17.
The pathogenic role of cystathionine γ-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice. [Am J Pathol. 2011]
The pathogenic role of cystathionine γ-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice.
Yang G, Tang G, Zhang L, Wu L, Wang R. Am J Pathol. 2011 Aug; 179(2):869-79. Epub 2011 Jun 2.
Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. [Aging (Albany NY). 2011]
Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans.
Weiss EP, Villareal DT, Fontana L, Han DH, Holloszy JO. Aging (Albany NY). 2011 May; 3(5):533-42.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The use of areas under curves in diabetes research.
The use of areas under curves in diabetes research.
Diabetes Care. 1995 Feb ;18(2):245-50.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: