Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Infect Agents Dis. 1995 Mar;4(1):29-40.

Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections.

Author information

  • 1Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201-3098, USA.

Abstract

The auxotrophy of parasitic protozoa for purines makes purine acquisition from the host a nutritional necessity for the survival and growth of these pathogens. The parasite hypoxanthine-guanine phosphoribosyltransferase (HGPRT) enzyme has been implicated as a critical enzyme in this purine salvage process. Moreover, the HGPRT enzyme in some parasites can also initiate the metabolism of purine base analogs that have little effect on the mammalian host. This implies that either inhibitors or substrates of HGPRT might serve as efficacious and selective agents for the treatment of parasitic diseases. This commentary provides an overview of recent molecular and biochemical studies on HGPRT proteins from parasitic protozoa and a discussion of the potential of HGPRT as a rational target for the chemotherapeutic manipulation of parasitic diseases.

PMID:
7728354
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk