Intern Med. 1995 Feb;34(2):108-11.

Periodic angioedema with eosinophilia: increased serum level of interleukin 5.

Okubo Y, Sato E, Hossain M, Ota T, Yoshikawa S, Sekiguchi M.

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First Department of Internal Medicine, School of Medicine, Shinshu University, Matsumoto.

Abstract

A 48-year-old man developed episodic non pitting edema and eosinophilia. Symptoms were alleviated promptly when treated with prednisolone. However, major basic protein (MBP), eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN) levels in the serum as well as the total number of eosinophils remained high. During periods of attack serum levels of interleukin-5 (IL-5) were elevated, but the levels were lowered following treatment, suggesting that IL-5 is involved in periodic angioedema with eosinophilia.

PMID:: 7727874; [PubMed - indexed for MEDLINE]

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