Vasa. 1995;24(1):56-61.

The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release.

Source

Department of Surgery, Faculty of Medicine, Kuwait University.

Abstract

Forskolin, a diterpene obtained from coleus forskolii, is a potent cAMP stimulator. We have evaluated the effects of forskolin on blood flow, platelet aggregation and metabolism. It was found that forskolin has a dose dependent vaso-relaxing effect in an in vivo sheep model, when infused intra-arterially. Furthermore forskolin, in a dose-dependent fashion reduced whole blood platelet aggregation and ATP release. Pretreatment of PTFE grafts with Forskolin significantly reduced platelet consumption 3 hours postoperatively and on the first postoperative day. The overall platelet metabolism, measured by a microcalorimetric technique after treatment with forskolin in vitro and ex-vivo postoperatively was significantly increased. In conclusion: Forskolin affects blood flow and platelet parameters favourably in the setting of occlusive arterial disease and reconstructive arterial surgery.

PMID:: 7725780; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Blood Thinners - MedlinePlus Health Information

Molecular Biology Databases

TEFLON - HSDB

Supplemental Content

Save items

Related citations in PubMed

Impregnation of polytetrafluoethylene (PTFE) vascular grafts with C-14-forskolin, a new concept in surface treatment of grafts. [Vasa. 1990]
Impregnation of polytetrafluoethylene (PTFE) vascular grafts with C-14-forskolin, a new concept in surface treatment of grafts.
Christenson JT, Thulesius O, Nazzal M. Vasa. 1990; 19(4):315-9.
Effects of forskolin and organic nitrate on aggregation and intracellular cyclic nucleotide content in human platelets. [Gen Pharmacol. 1994]
Effects of forskolin and organic nitrate on aggregation and intracellular cyclic nucleotide content in human platelets.
Anfossi G, Massucco P, Mularoni E, Cavalot F, Mattiello L, Trovati M. Gen Pharmacol. 1994 Oct; 25(6):1093-100.
Forskolin inhibits platelet deposition in small diameter polytetrafluoroethylene grafts. [J Cardiovasc Surg (Torino). 1989]
Forskolin inhibits platelet deposition in small diameter polytetrafluoroethylene grafts.
Christenson JT, Thulesius O, Al-Huneidi W. J Cardiovasc Surg (Torino). 1989 Jan-Feb; 30(1):81-4.
Forskolin impregnation of small calibre PTFE grafts lowers early platelet graft sequestration and improves patency in a sheep model. [Eur J Vasc Surg. 1991]
Forskolin impregnation of small calibre PTFE grafts lowers early platelet graft sequestration and improves patency in a sheep model.
Christenson JT, Thulesius O, Owunwanne A, Nazzal M. Eur J Vasc Surg. 1991 Jun; 5(3):271-5.
The potent inhibition of vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets. [Biol Pharm Bull. 1997]
The potent inhibition of vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets.
Horie S, Yamada M, Satoh M, Noritake S, Hiraishi S, Kizaki K, Kurusu O, Nakahara T, Ishii H, Kazama M. Biol Pharm Bull. 1997 Jun; 20(6):625-31.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP ...
The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release.
Vasa. 1995 ;24(1):56-61.

PubMed
[Insulin resistance and hyperlipoproteinemia].
[Insulin resistance and hyperlipoproteinemia].
Vnitr Lek. 1995 Feb ;41(2):105-9.

PubMed
[Effect of the steroid sex hormones on the LH and FSH responses to LHRH in the n...
[Effect of the steroid sex hormones on the LH and FSH responses to LHRH in the normal subject].
Pathol Biol (Paris). 1975 Dec ;23(10):917-22.

PubMed
[Injuries to the hyoid bone and laryngeal cartilages in hanging].
[Injuries to the hyoid bone and laryngeal cartilages in hanging].
Sud Med Ekspert. 1995 Jan-Mar ;38(1):37-8.

PubMed
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B an...
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.
FASEB J. 1995 Jul ;9(10):899-909.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information