Abstract
The effects of neurotrophins on several forms of neuronal degeneration in murine cortical cell cultures were examined. Consistent with other studies, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 all attenuated the apoptotic death induced by serum deprivation or exposure to the calcium channel antagonist nimodipine. Unexpectedly, however, 24-hour pretreatment with these same neurotrophins markedly potentiated the necrotic death induced by exposure to oxygen-glucose deprivation or N-methyl-D-aspartate. Thus, certain neurotrophins may have opposing effects on different types of death in the same neurons.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Apoptosis / drug effects
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Brain-Derived Neurotrophic Factor
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Calcium / metabolism
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Cell Death / drug effects
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Cells, Cultured
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Cerebral Cortex / cytology
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Dizocilpine Maleate / pharmacology
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Mice
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N-Methylaspartate / pharmacology
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Necrosis
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Nerve Degeneration / drug effects*
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Nerve Growth Factors / pharmacology*
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Nerve Tissue Proteins / pharmacology
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Neurons / cytology*
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Neurons / drug effects
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Neurons / pathology
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Neurotrophin 3
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Quinoxalines / pharmacology
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Receptors, AMPA / antagonists & inhibitors
Substances
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Brain-Derived Neurotrophic Factor
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Nerve Growth Factors
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Nerve Tissue Proteins
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Neurotrophin 3
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Quinoxalines
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Receptors, AMPA
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2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
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neurotrophin 5
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N-Methylaspartate
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Dizocilpine Maleate
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neurotrophin 4
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Calcium