Nature. 1995 May 4;375(6526):58-61.

Homeotic genes and the regulation and evolution of insect wing number.

Carroll SB, Weatherbee SD, Langeland JA.

Source

Howard Hughes Medical Institute, Madison, Wisconsin, USA.

Abstract

The evolution of wings catalysed the radiation of insects which make up some 75 per cent of known animals. Fossil evidence suggests that wings evolved from a segment of the leg and that early pterygotes bore wings on all thoracic and abdominal segments. The pterygote body plan subsequently diverged producing orders bearing three, two or just one pair of thoracic wings. We have investigated the role of homeotic genes in pterygote evolution by examining their function in Drosophila wing development and their expression in a primitive apterygote. Wing formation is not promoted by any homeotic gene, but is repressed in different segments by different homeotic genes. We suggest here that wings first arose without any homeotic gene involvement in an ancestor with a homeotic 'groundplan' similar to modern winged insects and that wing formation subsequently fell under the negative control of individual homeotic genes at different stages of pterygote evolution.

PMID:: 7723843; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

FlyBase

Supplemental Content

Save items

Related citations in PubMed

Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each. [Development. 1993]
Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each.
Breen TR, Harte PJ. Development. 1993 Jan; 117(1):119-34.
Evolution of the insect body plan as revealed by the Sex combs reduced expression pattern. [Development. 1997]
Evolution of the insect body plan as revealed by the Sex combs reduced expression pattern.
Rogers BT, Peterson MD, Kaufman TC. Development. 1997 Jan; 124(1):149-57.
Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity. [Development. 1993]
Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity.
Zeng W, Andrew DJ, Mathies LD, Horner MA, Scott MP. Development. 1993 Jun; 118(2):339-52.
Review Insect evolution: Redesigning the fruitfly. [Curr Biol. 1999]
Review Insect evolution: Redesigning the fruitfly.
Gibson G. Curr Biol. 1999 Feb 11; 9(3):R86-9.
Review Regulating the expression and function of homeotic genes. [Curr Opin Genet Dev. 1991]
Review Regulating the expression and function of homeotic genes.
Dessain S, McGinnis W. Curr Opin Genet Dev. 1991 Aug; 1(2):275-82.

See reviews... See all...

Cited by 25 PubMed Central articles

Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in Drosophila. [PLoS One. 2011]
Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in Drosophila.
Choo SW, White R, Russell S. PLoS One. 2011 Apr 5; 6(4):e14778. Epub 2011 Apr 5.
Hox gene Ultrabithorax regulates distinct sets of target genes at successive stages of Drosophila haltere morphogenesis. [Proc Natl Acad Sci U S A. 2011]
Hox gene Ultrabithorax regulates distinct sets of target genes at successive stages of Drosophila haltere morphogenesis.
Pavlopoulos A, Akam M. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2855-60. Epub 2011 Jan 31.
Review Chromosomal organization at the level of gene complexes. [Cell Mol Life Sci. 2011]
Review Chromosomal organization at the level of gene complexes.
Chopra VS. Cell Mol Life Sci. 2011 Mar; 68(6):977-90. Epub 2010 Nov 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Homeotic genes and the regulation and evolution of insect wing number.
Homeotic genes and the regulation and evolution of insect wing number.
Nature. 1995 May 4 ;375(6526):58-61.

PubMed
Placebo-controlled trial of safety and efficacy of intraoperative controlled del...
Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group.
Lancet. 1995 Apr 22 ;345(8956):1008-12.

PubMed
Anesthesia for surgery is American discovery.
Anesthesia for surgery is American discovery.
J S C Med Assoc. 1976 Mar ;72(3):101.

PubMed
Lower extremity injuries in drivers of airbag-equipped automobiles: clinical and...
Lower extremity injuries in drivers of airbag-equipped automobiles: clinical and crash reconstruction correlations.
J Trauma. 1995 Apr ;38(4):509-16.

PubMed
Measurement of drinking behavior using the Form 90 family of instruments.
Measurement of drinking behavior using the Form 90 family of instruments.
J Stud Alcohol Suppl. 1994 Dec ;12:112-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Homeotic genes and the regulation and evolution of insect wing number.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 25 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information