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    Gene. 1995 Apr 3;155(2):261-5.

    Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene.

    Lopez M, Eberlé F, Mattei MG, Gabert J, Birg F, Bardin F, Maroc C, Dubreuil P.

    Source

    INSERM U.119, Unité de Cancérologie et Thérapeutique Expérimentales, Marseille, France.

    Abstract

    The human poliovirus (PV) receptor (PVR) is a member of the immunoglobulin (Ig) superfamily with unknown cellular function. We have isolated a human PVR-related (PRR) cDNA. The deduced amino acid (aa) sequence of PRR showed, in the extracellular region, 51.7 and 54.3% similarity with human PVR and with the murine PVR homolog, respectively. The cDNA coding sequence is 1.6-kb long and encodes a deduced 57-kDa protein; this protein has a structural organization analogous to that of PVR, that is, one V- and two C-set Ig domains, with a conserved number of aa. Northern blot analysis indicated that a major 5.9-kb transcript is present in all normal human tissues tested. In situ hybridization showed that the PRR gene is located at bands q23-q24 of human chromosome 11.

    PMID:
    7721102
    [PubMed - indexed for MEDLINE]

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