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1: Gastrointest Endosc. 1995 Feb;41(2):99-104.Links
Comment in:
Gastrointest Endosc. 1995 Feb;41(2):173-5.

Efficacy, safety, and cost of intravenous sedation versus general anesthesia in children undergoing endoscopic procedures.

Squires RH Jr, Morriss F, Schluterman S, Drews B, Galyen L, Brown KO.

Division of Gastroenterology and Nutrition, University of Texas Southwestern Medical Center at Dallas 75235-9063, USA.

We prospectively evaluated 226 patients under 18 years of age who underwent 296 procedures, and intravenous sedation and general anesthesia were compared in regard to efficacy, safety, and cost. Children 6 to 9 years of age required the highest doses of midazolam (0.14 +/- 0.04 mg/kg) and meperidine (2.5 +/- 0.8 mg/kg). A Relative Adequacy Scale, constructed to assess each patient's arousal and cooperation during intravenous sedation, revealed a 95% completion rate. Heart rate monitored before, during, and after the procedure was similar in both groups during the procedure, but a lower preprocedure heart rate was noted in older patients having intravenous sedation, suggesting less patient anxiety. Average charges, excluding endoscopist's and pathology fees, were $768.52 in the intravenous sedation group versus $1,965.42 in the general anesthesia group. Endoscopic procedures can be performed safely, effectively, and at a lower cost to the patient under intravenous sedation in a properly equipped and staffed pediatric endoscopy suite.

PMID: 7721025 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Meperidine (Demerol® Hydrochloride, Demerol® Hydrochloride Syrup)

    Meperidine is used to relieve moderate to severe pain. Meperidine is in a class of medications called narcotic analgesics, a group of pain medications similar to morphine. It works by changing the way the body senses pai...

  • Midazolam (available generically)

    Midazolam is given to children before medical procedures or before anesthesia for surgery to cause drowsiness, relieve anxiety, and prevent any memory of the event. Midazolam is in a class of medications called benzodiaz...

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