Display Settings:

Format

Send to:

Choose Destination
    Science. 1995 Apr 21;268(5209):429-31.

    Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.

    Source

    Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, MA, USA.

    Abstract

    Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central unresolved issue in acquired immunodeficiency syndrome (AIDS) pathogenesis is the mechanism underlying this T cell depletion. HIV-1 Tat protein was shown to induce cell death by apoptosis in a T cell line and in cultured peripheral blood mononuclear cells from uninfected donors. This Tat-induced apoptosis was inhibitable by growth factors and was associated with enhanced activation of cyclin-dependent kinases.

    PMID:
    7716549
    [PubMed - indexed for MEDLINE]

      Supplemental Content

      Icon for HighWire Press

      Save items

      loading

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk