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Ann Emerg Med. 1995 Apr;25(4):520-4.

Effects of physical activity on creatine phosphokinase and the isoenzyme creatine kinase-MB.

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  • 1Department of Kinesiology, University of Northern Colorado, Greeley.


Creatine phosphokinase (CPK) and creatine kinase-MB (CK-MB) have been used extensively as diagnostic markers for myocardial infarction and skeletal muscle injury. Many factors affect the variability of serum CPK and serum CK-MB activity, especially physical activity. We discuss the influence of physical activity on muscle and serum CPK and CK-MB. The effect of acute and chronic exercise on CPK and CK-MB activity emphasizes the need to use measurements of serum CPK and CK-MB with caution when evaluating and diagnosing acute myocardial infarctions and skeletal muscle injury.

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