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Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2710-4.

A random-walk/giant-loop model for interphase chromosomes.

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  • 1Department of Mathematics, University of California, Berkeley 94720, USA.


Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G0/G1 part of the cell cycle may consist of flexible chromatin loops, averaging approximately 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data. More general models consistent with the data are briefly discussed.

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