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Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor.
Upjohn Company, Kalamazoo, MI 49001.
Two forms of cDNA coding for the human GABAA beta 2 subunit have been cloned and sequenced. The two sequences differ by a 114 base pair insertion. The insert contains a phosphorylation consensus sequence for calmodulin-dependent protein kinase II. Quantitative PCR studies show that h beta 2L cDNA represents 10-15% of total h beta 2 cDNA in the 10 brain substructures tested. Analysis of human genomic southern blots suggests that the two forms might arise by differential splicing.
PMID: 7707873 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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GABA(A) Receptors in Normal Development and Seizures: Friends or Foes?
Galanopoulou AS.
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[Curr Neuropharmacol. 2008]
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In silico comparative genomic analysis of GABAA receptor transcriptional regulation.
Joyce CJ.
BMC Genomics. 2007 Jun 30; 8:203. Epub 2007 Jun 30.
[BMC Genomics. 2007]
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Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain.
Palma E, Ragozzino DA, Di Angelantonio S, Spinelli G, Trettel F, Martinez-Torres A, Torchia G, Arcella A, Di Gennaro G, Quarato PP, et al.
Proc Natl Acad Sci U S A. 2004 Jul 6; 101(27):10183-8. Epub 2004 Jun 24.
[Proc Natl Acad Sci U S A. 2004]