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Ann Plast Surg. 1995 Jan;34(1):103-9.

Silicone breast implants and autoimmune connective tissue disease.

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  • 1Division of Plastic Surgery, Wellesley Hospital, Toronto, Ontario, Canada.

Abstract

There is currently no proven cause-and-effect relationship between breast implants and autoimmune connective tissue disease. However, there is a growing concern that immunological sensitization to silicone could potentially develop in certain susceptible patients and that this could contribute to the development of autoimmune connective tissue disease. In this article I review the current status of this potential relationship. The following areas are discussed: chemistry of silicone, potential mechanisms for an immune response, implant failure, epidemiological and antibody studies of autoimmune connective tissue disease, and recent information on certain neurological findings in a group of patients with breast implants. Current large-scale epidemiological studies should help to define any potential relationship between breast implants and autoimmune connective tissue disease.

PMID:
7702292
[PubMed - indexed for MEDLINE]
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