Abstract
Six of 11 human immunodeficiency virus (HIV)-infected patients with chronic diarrhea, shedding only Candida spp. in their stools, elicited a Candida-specific secretory immunoglobulin A response. Similar responses were identified in only 1 of 10 HIV-positive patients with chronic diarrhea but without Candida spp. and in none of 10 HIV-negative subjects without diarrhea. Candida spp. may play a role in the etiology of chronic diarrhea associated with HIV infection.
MeSH terms
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AIDS-Related Opportunistic Infections / immunology*
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AIDS-Related Opportunistic Infections / microbiology
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Antigens, Fungal
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Blotting, Western
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Candidiasis / immunology*
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Candidiasis / virology
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Chronic Disease
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Diarrhea / immunology*
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Diarrhea / microbiology
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Diarrhea / virology
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Electrophoresis, Polyacrylamide Gel
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Enzyme-Linked Immunosorbent Assay
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Feces / chemistry
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Feces / microbiology
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HIV Infections / immunology*
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HIV Infections / microbiology
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Humans
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Immunoglobulin A, Secretory / analysis*
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Immunoglobulin A, Secretory / biosynthesis*
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Intestinal Mucosa / immunology*
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Intestinal Mucosa / metabolism*
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Sodium Dodecyl Sulfate
Substances
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Antigens, Fungal
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Immunoglobulin A, Secretory
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Sodium Dodecyl Sulfate