Glycoconj J. 1994 Dec;11(6):527-32.

Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions.

Source

Cancer Metastasis Program, Michigan Cancer Foundation, Detroit 48201.

Abstract

Citrus pectin (CP) and pH-modified citrus pectin (MCP) are highly branched and non-branched complex polysaccharides, respectively, rich in galactoside residues, capable of combining with the carbohydrate-binding domain of galectin-3. We reported previously that intravenous injection of B16-F1 murine melanoma cells with CP or MCP into syngeneic mice resulted in a significant increase or decrease of lung colonization, respectively (Platt D, Raz A (1992) J Natl Cancer Inst 84:438-42). Here we studied the effects of these polysaccharides on cell-cell and cell-matrix interactions mediated by carbohydrate-recognition. MCP, but not CP, inhibited B16-F1 melanoma cells adhesion to laminin and asialofetuin-induced homotypic aggregation. Both polysaccharides inhibited anchorage-independent growth of B16-F1 cells in semisolid medium, i.e. agarose. These results indicate that carbohydrate-recognition by cell surface galectin-3 may be involved in cell-extracellular matrix interaction and play a role in anchorage-independent growth as well as the in vivo embolization of tumour cells.

PMID:: 7696855; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin. [J Natl Cancer Inst. 1992]
Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin.
Platt D, Raz A. J Natl Cancer Inst. 1992 Mar 18; 84(6):438-42.
Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. [J Natl Cancer Inst. 2002]
Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin.
Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R, Raz A. J Natl Cancer Inst. 2002 Dec 18; 94(24):1854-62.
Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. [J Natl Cancer Inst. 1995]
Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin.
Pienta KJ, Naik H, Akhtar A, Yamazaki K, Replogle TS, Lehr J, Donat TL, Tait L, Hogan V, Raz A. J Natl Cancer Inst. 1995 Mar 1; 87(5):348-53.
Review Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. [Carbohydr Res. 2009]
Review Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.
Glinsky VV, Raz A. Carbohydr Res. 2009 Sep 28; 344(14):1788-91. Epub 2008 Sep 26.
Review Role of galectin-3 as a receptor for advanced glycosylation end products. [Kidney Int Suppl. 2000]
Review Role of galectin-3 as a receptor for advanced glycosylation end products.
Pricci F, Leto G, Amadio L, Iacobini C, Romeo G, Cordone S, Gradini R, Barsotti P, Liu FT, Di Mario U, et al. Kidney Int Suppl. 2000 Sep; 77:S31-9.

See reviews... See all...

Cited by 10 PubMed Central articles

Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin. [BMC Complement Altern Med. 2011]
Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin.
Ramachandran C, Wilk BJ, Hotchkiss A, Chau H, Eliaz I, Melnick SJ. BMC Complement Altern Med. 2011 Aug 4; 11:59. Epub 2011 Aug 4.
Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury. [PLoS One. 2011]
Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury.
Kolatsi-Joannou M, Price KL, Winyard PJ, Long DA. PLoS One. 2011 Apr 8; 6(4):e18683. Epub 2011 Apr 8.
Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment. [Cell Death Dis. 2010]
Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment.
Wang Y, Nangia-Makker P, Balan V, Hogan V, Raz A. Cell Death Dis. 2010 Nov 18; 1:e101. Epub 2010 Nov 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell ...
Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions.
Glycoconj J. 1994 Dec ;11(6):527-32.

PubMed
Changes in cell growth, cyclin/kinase, endogenous phosphoproteins and nm23 gene ...
Changes in cell growth, cyclin/kinase, endogenous phosphoproteins and nm23 gene expression in human prostatic JCA-1 cells treated with modified citrus pectin.
Biochem Mol Biol Int. 1995 Nov ;37(5):833-41.

PubMed
Microbial populations in Antarctic permafrost: biodiversity, state, age, and imp...
Microbial populations in Antarctic permafrost: biodiversity, state, age, and implication for astrobiology.
Astrobiology. 2007 Apr ;7(2):275-311.

PubMed
Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ...
Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice.
Science. 2009 Jul 24 ;325(5939):484-7. Epub 2009 Jul 2 .

PubMed
Evidence-based labor and delivery management.
Evidence-based labor and delivery management.
Am J Obstet Gynecol. 2008 Nov ;199(5):445-54.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Cited by 10 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information