Neurology. 1993 Nov;43(11):2193-6.

Sensory neuropathy associated with Dursban (chlorpyrifos) exposure.

Kaplan JG, Kessler J, Rosenberg N, Pack D, Schaumburg HH.

Source

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.

Erratum in

Neurology 1994 Feb;44(2):367.

Abstract

Chlorpyrifos (Dursban) is an organophosphate insecticide with extensive domestic and agricultural applications. It is regarded as safe for these purposes; one report of neurotoxicity is attributed to massive ingestion in a suicide attempt. We report eight people who developed peripheral neuropathy after exposure to exterminator-applied commercial Dursban; five also experienced memory loss and cognitive slowing. Evaluation failed to reveal other causes of neurologic dysfunction; symptoms recurred in one patient following accidental reexposure. We conclude that environmental contact with chlorpyrifos can cause sensory neuropathy and CNS dysfunction and that this agent should be used with caution.

PMID:: 7694187; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

Chlorpyrifos

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Poisoning by organophosphorus insecticides and sensory neuropathy. [J Neurol Neurosurg Psychiatry....]
Poisoning by organophosphorus insecticides and sensory neuropathy.
Moretto A, Lotti M. J Neurol Neurosurg Psychiatry. 1998 Apr; 64(4):463-8.
The effects of occupational exposure to chlorpyrifos on the peripheral nervous system: a prospective cohort study. [Occup Environ Med. 2004]
The effects of occupational exposure to chlorpyrifos on the peripheral nervous system: a prospective cohort study.
Albers JW, Garabrant DH, Schweitzer SJ, Garrison RP, Richardson RJ, Berent S. Occup Environ Med. 2004 Mar; 61(3):201-11.
Neurologic function among termiticide applicators exposed to chlorpyrifos. [Environ Health Perspect. 2000]
Neurologic function among termiticide applicators exposed to chlorpyrifos.
Steenland K, Dick RB, Howell RJ, Chrislip DW, Hines CJ, Reid TM, Lehman E, Laber P, Krieg EF Jr, Knott C. Environ Health Perspect. 2000 Apr; 108(4):293-300.
Review Chlorpyrifos: an unwelcome pesticide in our homes. [Rev Environ Health. 2000]
Review Chlorpyrifos: an unwelcome pesticide in our homes.
Lemus R, Abdelghani A. Rev Environ Health. 2000 Oct-Dec; 15(4):421-33.
Review Analysis of chlorpyrifos exposure and human health: expert panel report. [J Toxicol Environ Health B Cri...]
Review Analysis of chlorpyrifos exposure and human health: expert panel report.
Albers JW, Cole P, Greenberg RS, Mandel JS, Monson RR, Ross JH, Snodgrass WR, Spurgeon A, van Gemert M. J Toxicol Environ Health B Crit Rev. 1999 Oct-Dec; 2(4):301-24.

See reviews... See all...

Cited by 8 PubMed Central articles

The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice. [J Occup Med Toxicol. 2011]
The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice.
Lim KL, Tay A, Nadarajah VD, Mitra NK. J Occup Med Toxicol. 2011 Mar 8; 6(1):4. Epub 2011 Mar 8.
Microtubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity. [Neuroscience. 2007]
Microtubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity.
Prendergast MA, Self RL, Smith KJ, Ghayoumi L, Mullins MM, Butler TR, Buccafusco JJ, Gearhart DA, Terry AV Jr. Neuroscience. 2007 Apr 25; 146(1):330-9. Epub 2007 Feb 22.
The effects of occupational exposure to chlorpyrifos on the peripheral nervous system: a prospective cohort study. [Occup Environ Med. 2004]
The effects of occupational exposure to chlorpyrifos on the peripheral nervous system: a prospective cohort study.
Albers JW, Garabrant DH, Schweitzer SJ, Garrison RP, Richardson RJ, Berent S. Occup Environ Med. 2004 Mar; 61(3):201-11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Sensory neuropathy associated with Dursban (chlorpyrifos) exposure.
Sensory neuropathy associated with Dursban (chlorpyrifos) exposure.
Neurology. 1993 Nov ;43(11):2193-6.

PubMed
T cell peptide of a self-protein elicits autoantibody to the protein antigen. Im...
T cell peptide of a self-protein elicits autoantibody to the protein antigen. Implications for specificity and pathogenetic role of antibody in autoimmunity.
J Immunol. 1993 Nov 15 ;151(10):5790-9.

PubMed
[The theoretical analysis of Fick's equation. On the centennial of the use of Fi...
[The theoretical analysis of Fick's equation. On the centennial of the use of Fick's principle in physiology].
Z Kardiol. 1975 Sep ;64(9):801-8.

PubMed
FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes a...
FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts.
J Biol Chem. 1993 Nov 15 ;268(32):24270-3.

PubMed
Alpha 2-macroglobulin and pregnancy zone protein. Serum levels, alpha 2-macroglo...
Alpha 2-macroglobulin and pregnancy zone protein. Serum levels, alpha 2-macroglobulin receptors, cellular synthesis and aspects of function in relation to immunology.
Dan Med Bull. 1993 Sep ;40(4):409-46.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Sensory neuropathy associated with Dursban (chlorpyrifos) exposure.

Source

Erratum in

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information