Abstract
The structure of glutamine synthetase (GS) enzymes from diverse bacterial groups fall into three distinct classes. GSI is the typical bacterial GS, GSII is similar to the eukaryotic GS and is found together with GSI in plant symbionts and Streptomyces, while GSIII has been found in two unrelated anaerobic rumen bacteria. In most cases, the structural gene for GS enzyme is regulated in response to nitrogen. However, different regulatory mechanisms, to ensure optimal utilization of nitrogen substrates, control the GS enzyme in each class.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Actinomycetales / enzymology
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Actinomycetales / genetics
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Bacillus / enzymology
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Bacillus / genetics
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Bacteria / enzymology*
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Bacteria / genetics
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Base Sequence
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Clostridium / enzymology
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Clostridium / genetics
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics
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Gene Expression Regulation, Enzymologic
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Glutamate-Ammonia Ligase / chemistry
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Glutamate-Ammonia Ligase / genetics
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Glutamate-Ammonia Ligase / metabolism*
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Molecular Sequence Data
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Molecular Structure
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RNA, Bacterial / genetics
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Rhizobiaceae / enzymology
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Rhizobiaceae / genetics
Substances
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RNA, Bacterial
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Glutamate-Ammonia Ligase