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    Neurosci Lett. 1993 Jun 11;155(2):136-9.

    Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit.

    Willoughby JJ, Ninkina NN, Beech MM, Latchman DS, Wood JN.

    Source

    Sandoz Institute for Medical Research, London, UK.

    Abstract

    Three cDNA clones homologous to rat neuronal nicotinic receptors were identified in a human brain stem library by screening at low stringency with a mixture of rat alpha 5, beta 2 and beta 4 subunit probes. Positive clones were further analysed by hybridisation at higher stringency with individual rat nicotinic receptor probes. One positive clone was found to encode a protein that exhibited characteristic features of a member of the ligand-gated ion channel class of protein subunits, and showed 89% homology with a rat beta 3 neuronal nicotinic receptor subunit. Northern blots demonstrated the presence of a 1.7 kb transcript in RNA extracted from adult human Pons. This clone has therefore been designated the human beta 3 neuronal nicotinic receptor subunit.

    PMID:
    7690916
    [PubMed - indexed for MEDLINE]

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