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Science. 1993 Jul 9;261(5118):221-4.

mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels.

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  • 1Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.

Abstract

Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.

PMID:
7687074
[PubMed - indexed for MEDLINE]
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