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    Science. 1993 Jul 9;261(5118):221-4.

    mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels.

    Butler A, Tsunoda S, McCobb DP, Wei A, Salkoff L.

    Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.

    Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.

    PMID: 7687074 [PubMed - indexed for MEDLINE]

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