Localization of the human interferon-induced, ds-R...[Genomics. 1993]

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1: Genomics. 1993 Jun;16(3):768-70. Links

Localization of the human interferon-induced, ds-RNA activated p68 kinase gene (PRKR) to chromosome 2p21-p22.

Squire J, Meurs EF, Chong KL, McMillan NA, Hovanessian AG, Williams BR.

Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.

The interferon-induced dsRNA-activated protein kinase (PRKR) belongs to a subclass of serine/threonine kinases, involved in the regulation of protein synthesis by phosphorylation of the alpha subunit of initiation factor eIF2. Somatic cell hybrids segregating human chromosomes were used to assign this kinase to human chromosome 2. Fluorescence in situ hybridization confirmed this assignment and further localized the gene (PRKR) to the boundary region of bands p21 and 22.

PMID: 7686884 [PubMed - indexed for MEDLINE]

Chromosomal assignment of the interferon-inducible double-stranded RNA-dependent protein kinase (PRKR) to human chromosome 2p21-p22 and mouse chromosome 17 E2.
Genomics. 1993 Jun; 16(3):765-7.

[Genomics. 1993]
Mapping of the gene for interferon-inducible dsRNA-dependent protein kinase to chromosome region 2p21-22: a site of rearrangements in myeloproliferative disorders.
Genes Chromosomes Cancer. 1993 Sep; 8(1):34-7.

[Genes Chromosomes Cancer. 1993]
Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.
Mol Cell Biol. 1991 Nov; 11(11):5497-505.

[Mol Cell Biol. 1991]
ReviewInterferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2',5'-oligoadenylate synthetases.
J Interferon Res. 1991 Aug; 11(4):199-205.

[J Interferon Res. 1991]
ReviewPKR--a protein kinase regulated by double-stranded RNA.
Int J Biochem Cell Biol. 1997 Jul; 29(7):945-9.

[Int J Biochem Cell Biol. 1997]
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Cited by 4 PubMed Central articles

Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes.
Rios JJ, Perelygin AA, Long MT, Lear TL, Zharkikh AA, Brinton MA, Adelson DL. BMC Genomics. 2007 Sep 7; 8:313. Epub 2007 Sep 7.

[BMC Genomics. 2007]
ReviewImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative action.
García MA, Gil J, Ventoso I, Guerra S, Domingo E, Rivas C, Esteban M. Microbiol Mol Biol Rev. 2006 Dec; 70(4):1032-60.

[Microbiol Mol Biol Rev. 2006]
ReviewAntiviral actions of interferons.
Samuel CE. Clin Microbiol Rev. 2001 Oct; 14(4):778-809, table of contents.

[Clin Microbiol Rev. 2001]
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Localization of the human interferon-induced, ds-RNA activated p68 kinase gene (PRKR) to chromosome 2p21-p22.

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Cited by 4 PubMed Central articles

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