Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genes Chromosomes Cancer. 1993 Apr;6(4):245-8.

The human NME2 gene lies within 18kb of NME1 in chromosome 17.

Author information

  • 1University of Michigan, Human Genome Center 48109-0650.

Abstract

The NME1 gene, localized to human chromosome 17 at q22, shows reduced expression in tumors of high metastatic potential. A homologous gene, NME2, with similar reduced expression in breast carcinoma, has recently been reported. We have isolated and characterized five yeast artificial chromosome (YAC) clones and three cosmid clones that contain both genes, demonstrating that the NME2 gene is also located on chromosome 17 and is separated by not more than 18 kb from the NME1 gene. The two putative tumor suppressor genes, encoding the two polypeptide chains of nucleoside diphosphate (NDP) kinase, are thus quite close to each other on chromosome 17, indicating that they may well have arisen by a tandem duplication. Both genes now appear to be excluded as candidates for the early-onset breast cancer (BRCA1) locus.

PMID:
7685630
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk