Format

Send to

Choose Destination
See comment in PubMed Commons below
Melanoma Res. 1993 Feb;3(1):5-14.

The possible role of angiogenesis in the metastatic potential of human melanoma. Clinicopathological aspects.

Author information

  • 1Department of Pathology, University Hospital Nijmegen, The Netherlands.

Abstract

In this review, we present a literature survey of angiogenesis in melanoma. Progression in melanoma is supposed to be associated with an angiogenic response. Several histological studies have shown an increase of vascular structures in malignant melanoma, which is not the case in common naevocellular naevi. Neovascularization can be caused by several angiogenic factors: the most important of those produced in melanoma are described. Proteases such as urokinase plasminogen activator and metalloproteinases are important for the migration for both endothelial cells and tumour cells. Possible effects of these factors in melanoma cells are discussed. Finally, inhibition of angiogenesis and its potential role in melanoma therapy are considered.

PMID:
7682462
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk