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Lancet. 1993 Apr 17;341(8851):1006-8.

The "trap" hypothesis of venous ulceration.

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  • 1University of Miami School of Medicine, Department of Dermatology and Cutaneous Surgery, Florida 33101.

Abstract

The pathogenesis of venous ulceration is unknown. We propose that macromolecules leaking into the dermis as a result of venous hypertension bind to or "trap" growth factors and matrix material, which then become unavailable for tissue repair and for the maintenance of tissue integrity.

PMID:
7682272
[PubMed - indexed for MEDLINE]
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