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Nature. 1993 Mar 11;362(6416):127-33.

Primary structure and functional expression of a mouse inward rectifier potassium channel.

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  • 1Howard Hughes Medical Institute, University of California, San Francisco 94143-0724.


A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.

[PubMed - indexed for MEDLINE]
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