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Nature. 1993 Mar 4;362(6415):31-8.

Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.

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  • 1Harvard Center for the Study of Kidney Disease, Harvard Medical School, Boston, Massachusetts.


A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.

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