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Psychopharmacology (Berl). 1995 Jun;119(3):311-4.

Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man.

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  • 1Department of Psychiatry, Royal London Hospital, St Clement's, UK.


The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man.

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