Metastases of colorectal carcinoma seem the most common liver tumors in our patients. Up to date clinical studies reveal in these the best results with intraarterial chemotherapy employing continuous or intermittent infusions of fluoropyrimidins. These require permanent vascular access. Techniques of implantation in normal an abnormal vascular anatomy, methodology of catheter patency maintenance, port maintenance and salvage of malfunction catheter feature as a group of new, technical and surgical problems. Together with the simultaneously solved problems as effective anticancer agents option and way of their administration they jointly condition a favourable effect of regional chemotherapy. The technical and surgical aspects result in further indication criteria for intraarterial chemotherapy, which is then conducted in a close cooperation of a surgeon and clinical oncologist.