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Drug Saf. 1995 May;12(5):299-304.

Anaphylactoid and anaphylactic reactions. Hazards of beta-blockers.

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  • 1Department of Medicine, Hahnemann University Hospital, Philadelphia, USA.


Studies have demonstrated greater hazards associated with anaphylaxis in patients receiving beta-blockers. Serious anaphylaxis is more frequent. Evidence suggests this occurs via modulation of adenylate cyclase, which can influence release of anaphylactogenic mediators. Treatment of anaphylaxis in patients exposed to beta-blockers is complicated because therapeutic administration of epinephrine (adrenaline) may be ineffective or promote undesired alpha-adrenergic and vagotonic effects. Risk reduction efforts should be considered for patients receiving beta-blockers who are prone to experience anaphylaxis.

[PubMed - indexed for MEDLINE]
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