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Science. 1995 Sep 15;269(5230):1583-5.

Requirement of MIP-1 alpha for an inflammatory response to viral infection.

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  • 1Department of Pathology, University of North Carolina, Chapel Hill 27599-7525, USA.

Abstract

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.

PMID:
7667639
[PubMed - indexed for MEDLINE]
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