Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. I. Identity of the producing organism, fermentation and biological activity

M Jackson; D J Frost; J P Karwowski; P E Humphrey; S K Dahod; W S Choi; K Brandt; L H Malmberg; R R Rasmussen; M H Scherr

doi:10.7164/antibiotics.48.608

Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. I. Identity of the producing organism, fermentation and biological activity

J Antibiot (Tokyo). 1995 Jul;48(7):608-13. doi: 10.7164/antibiotics.48.608.

Authors

M Jackson¹, D J Frost, J P Karwowski, P E Humphrey, S K Dahod, W S Choi, K Brandt, L H Malmberg, R R Rasmussen, M H Scherr, et al.

Affiliation

¹ Abbott Laboratories, Abbott Park, IL 60064, USA.

PMID: 7649856
DOI: 10.7164/antibiotics.48.608

Abstract

The fuscandins, antifungal agents of the papulacandin class, are produced by a strain of Fusarium sambucinum. Fermentation yielded 60 mg/liter of fusacandin A and minor amounts of fusacandin B. As expected, the fusacandins inhibit (1,3)-beta-glucan synthesis. Fusacandin A is slightly less active than papulacandin B against Candida albicans and, like papulacandin, loses activity in the presence of serum.

Publication types

Comparative Study

MeSH terms

Aminoglycosides*
Anti-Bacterial Agents / pharmacology
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology*
Candida albicans / drug effects
Fatty Acids, Unsaturated / isolation & purification
Fatty Acids, Unsaturated / pharmacology
Fermentation
Fusarium
Microbial Sensitivity Tests
Oligosaccharides / isolation & purification
Oligosaccharides / pharmacology

Substances

Aminoglycosides
Anti-Bacterial Agents
Antifungal Agents
Fatty Acids, Unsaturated
Oligosaccharides
fusacandin A
fusacandin B
papulacandin B