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FEBS Lett. 1995 Aug 14;370(1-2):32-6.

Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.

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  • 1Max-Planck-Institüt für experimentelle Medizin, Abteilung 11, Göttingen, Germany.

Abstract

Mammalian voltage-activated Shaker K+ channels associate with at least three cytoplasmic proteins: Kv beta 1, Kv beta 2 and Kv beta 3. These beta subunits contain variable N-termini, which can modulate the inactivation of Shaker alpha subunits, but are homologous throughout an aldo-keto reductase core. Human and ferret beta 3 proteins are identical with rat beta 1 throughout the core while beta 2 proteins are not; beta 2 also contains a shorter N-terminus and has no reported physiological role. We report that human beta 1 and beta 3 are derived from the same gene and that beta 2 modulates the inactivation properties of Kv1.4 alpha subunits.

PMID:
7649300
[PubMed - indexed for MEDLINE]
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