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    FEBS Lett. 1995 Aug 7;369(2-3):326-30.

    Molecular cloning and sequence analysis of human preprocathepsin C.

    Paris A, Strukelj B, Pungercar J, Renko M, Dolenc I, Turk V.

    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia.

    A cDNA clone (C1) coding for human preprocathepsin C was isolated from a human ileum cDNA library using a rat kidney-derived RT-PCR probe and its complete nucleotide sequence determined. The full-length 1857 bp sequence codes for a protein of 463 amino acid residues with a calculated molecular mass of 51848 Da. Comparison of the deduced amino acid sequence with that of rat preprocathepsin C indicates an 87.5% identity. A multiple alignment of the deduced cathepsin C sequence of 233 residues which, by analogy to other cystein proteinases, corresponds to the mature protein, confirms that human cathepsin C belongs to the papain superfamily.

    PMID: 7649281 [PubMed - indexed for MEDLINE]

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