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Trends Biotechnol. 1995 Jul;13(7):259-64.

The genetic engineering of microbial solvent production.

Author information

  • Microbiology Department, University of Cape Town, Rondebosch, South Africa.


Although the production of acetone and butanol by Clostridium strains was a thriving industrial fermentation process, it is no longer competitive with the chemical synthesis of solvents and has been discontinued. However, studies on the molecular biology of Clostridium strains suggest that genetic engineering for improved solvent production is feasible, and could result in the revival of the industrial fermentation process.

[PubMed - indexed for MEDLINE]
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