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Cancer Res. 1995 Sep 1;55(17):3739-41.

Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors.

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  • 1Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Abstract

We have investigated whether there is a quantitative relationship between the insulin-like growth factor I receptor (IGF-IR), the extent of apoptosis in vivo, and tumorigenesis. C6 rat glioblastoma cells were treated with increasing concentrations of antisense oligodeoxynucleotides to the IGF-IR RNA. The extent of apoptosis in vivo is correlated to the decrease in IGF-IR levels and, in turn, tumorigenesis in nude mice is correlated to the fraction of surviving cells. In syngeneic rats, a host response leads to complete inhibition of tumorigenesis. These findings establish, for the first time on a quantitative basis, the relationship between IGF-IR levels and the extent of apoptosis, as well as the relationship between the initial apoptotic event and the time of appearance of transplantable tumors.

PMID:
7641185
[PubMed - indexed for MEDLINE]
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