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Nature. 1995 Aug 10;376(6540):490-8.

Structure of serum response factor core bound to DNA.

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  • 1Institut für Molekularbiologie und Biophysik, ETH-Hönggerberg, Zürich, Switzerland.


The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.

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