Lancet. 1995 Aug 19;346(8973):459-61.

Thromboprophylaxis with low-molecular-weight heparin in outpatients with plaster-cast immobilisation of the leg.

Kock HJ, Schmit-Neuerburg KP, Hanke J, Rudofsky G, Hirche H.

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Department of Trauma Surgery, University Hospital Essen, Germany.

Abstract

Deep-vein thrombosis is common after plaster-cast immobilisation for traumatic injury. We did a randomised prospective study of the effect of low-molecular-weight heparin on the incidence of deep-vein thrombosis in patients with minor injuries treated with plaster-cast immobilisation of the leg. A control group (n = 163) received no prophylaxis, the prophylaxis group received low-molecular-weight heparin once daily (n = 176). The incidence of deep-vein thrombosis in the prophylaxis group was 0% (one tailed p < 0.006) vs 4.3% in the control group. No severe side-effects of low-molecular-weight heparin were observed. Thromboprophylaxis with low-molecular-weight heparin once daily is effective in reducing the risk of deep-vein thrombosis in outpatients with plaster-cast immobilisation of the leg.

PMID:: 7637478; [PubMed - indexed for MEDLINE]

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Thromboprophylaxis with low-molecular-weight heparin in outpatients with plaster-cast immobilisation of the leg.

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