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Arch Surg. 1995 Aug;130(8):892-7; discussion 898-9.

Familial nonmedullary thyroid cancer. An emerging entity that warrants aggressive treatment.

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  • 1Department of Surgery, Mount Zion Medical Center, University of California at San Francisco, USA.

Abstract

OBJECTIVE:

To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of follicular cell origin.

DESIGN:

Retrospective review.

SETTING:

University medical center.

PATIENTS:

Fourteen patients were treated for familial nonmedullary thyroid carcinoma between 1980 and 1994. Thirteen families were identified, with 30 affected individuals.

INTERVENTIONS:

Patients were treated with total or completion total thyroidectomy. Thirteen additional operations were performed to control recurrent disease.

MAIN OUTCOME MEASURES:

Stage, recurrence, and survival. Patients were followed up for a mean of 6.5 years.

RESULTS:

In our 14 patients, 13 tumors were multifocal, and six of these were bilateral. The incidences of lymph node metastasis and local invasion were both 57% (n = 8). Seven patients (50%) had recurrences during follow-up.

CONCLUSIONS:

Familial nonmedullary thyroid carcinoma has a high incidence of multifocality and invasion and a high rate of local recurrence. Aggressive initial treatment and careful follow-up seem to be indicated.

Comment in

PMID:
7632152
[PubMed - indexed for MEDLINE]
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