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Runaway telomere elongation caused by telomerase RNA gene mutations.
Department of Microbiology and Immunology, University of California at San Francisco 94143, USA.
The ribonucleoprotein enzyme telomerase adds telomeric DNA onto chromosome ends and is normally regulated so that telomeric DNA lengths are kept within defined bounds. In the telomerase RNA gene from the yeast Kluyveromyces lactis, specific mutations that alter telomeric DNA sequences result in telomeres elongating to up to 100 times their normal length and impair cell growth. Some mutations cause immediate elongation whereas others behave like genetic time bombs, causing elongation only after a latent period of hundreds of generations.
PMID: 7630414 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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End joining at Caenorhabditis elegans telomeres.
Lowden MR, Meier B, Lee TW, Hall J, Ahmed S.
Genetics. 2008 Oct; 180(2):741-54. Epub 2008 Sep 9.
[Genetics. 2008]
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Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA.
Webb CJ, Zakian VA.
Nat Struct Mol Biol. 2008 Jan; 15(1):34-42. Epub 2007 Dec 23.
[Nat Struct Mol Biol. 2008]
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Telomerase core components protect Candida telomeres from aberrant overhang accumulation.
Hsu M, McEachern MJ, Dandjinou AT, Tzfati Y, Orr E, Blackburn EH, Lue NF.
Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11682-7. Epub 2007 Jul 3.
[Proc Natl Acad Sci U S A. 2007]
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