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hBD-1: a novel beta-defensin from human plasma.
Niedersächsisches Institut für Peptid-Forschung, Hannover, Germany.
We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate. The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD-1 shares the nine conserved amino acids characteristic for beta-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.
PMID: 7628632 [PubMed - indexed for MEDLINE]
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Cited by 62 PubMed Central articles
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[Proteomics Clin Appl. 2008]
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