Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Interferon Cytokine Res. 1995 Apr;15(4):279-84.

Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?

Author information

  • 1Centre for Molecular and Cellular Biology, University of Queensland, Australia.

Abstract

The op/op mouse has a mutation in the macrophage colony-stimulating (CSF-1) gene. The phenotype of gross deficiency in the macrophage and osteoclast lineages corrects significantly with age, suggesting that other factors can substitute for CSF-1. This review examines the evidence that the op/op mouse is completely CSF-1 deficient and considers the possibility that alternative splicing within the CSF-1 gene might bypass the mutation, yielding an incompletely penetrant phenotype.

PMID:
7627801
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk