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Science. 1995 Jul 14;269(5221):230-4.

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.

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  • 1Department of Genetics, Case Western Reserve University, Cleveland, OH 44106-4955, USA.

Abstract

Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.

PMID:
7618084
[PubMed - indexed for MEDLINE]
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