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Obstet Gynecol. 1995 Aug;86(2):223-9.

Interleukin-8 synthesis and the onset of labor.

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  • 1Department of Obstetrics and Gynecology, University of Göttingen, Germany.

Abstract

OBJECTIVE:

To examine the role of cytokines in cervical dilation.

METHODS:

In 55 patients undergoing cesarean delivery, we took samples from the lower uterine segment, the decidua, and the membranes. We determined the concentrations of interleukin (IL)-2, IL-8, tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-8, and MMP-9 in the different tissues.

RESULTS:

Depending on the state of labor, we observed a significant increase (P < .001) in IL-8 concentrations in the lower uterine segment. The leukocyte enzymes MMP-8 and MMP-9 were highly significantly correlated with the IL-8 concentrations.

CONCLUSION:

Interleukin-8 is critically involved in the process of parturition in humans. Interleukin-8 concentrations in the myometrium, decidua, and membranes correlated strongly with the observed MMP-8 and MMP-9 concentrations.

PMID:
7617353
[PubMed - indexed for MEDLINE]
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