Diabetologia. 1979 Jan;16(1):25-30.

Worsening to diabetes in men with impaired glucose tolerance ("borderline diabetes").

Jarrett RJ, Keen H, Fuller JH, McCartney M.

Abstract

Two hundred and four men with impaired glucose tolerance (borderline diabetes) discovered in a screening examination have been observed for five years and repeated tests of glucose tolerance performed. By pre-determined criteria 27 men 'worsened to diabetes' and this metabolic deterioration was not significantly influenced by treatment with carbohydrate restriction with or without a daily dose of 50 mg phenformin. Of the baseline variables measured prior to treatment allocation only the blood glucose values were significantly predictive of ultimate worsening to diabetes.

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