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    Nature. 1995 Jul 20;376(6537):230-5.

    Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

    Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, Narula SK.

    Source

    Department of Pharmacology, University of Alabama at Birmingham 35294, USA.

    Abstract

    The crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 A. Upon receptor binding, the flexible AB loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix.

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    PMID:
    7617032
    [PubMed - indexed for MEDLINE]

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