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Nature. 1995 Jul 20;376(6537):230-5.

Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

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  • 1Department of Pharmacology, University of Alabama at Birmingham 35294, USA.

Abstract

The crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 A. Upon receptor binding, the flexible AB loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix.

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PMID:
7617032
[PubMed - indexed for MEDLINE]
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