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    Maturitas. 1995 Apr;21(3):251-7.

    Influence of route of administration on progesterone metabolism.

    de Lignieres B, Dennerstein L, Backstrom T.

    Département d'endocrinologie et Médecine de la Reproduction, Hopital Necker, Paris, France.

    While inducing similar progesterone levels, the ratio of 5 alpha- and 5 beta-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5 alpha- and 5 beta-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.

    PMID: 7616875 [PubMed - indexed for MEDLINE]

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      Progesterone is used as a part of hormone replacement therapy in women who have passed menopause (the change of life) and have not had a hysterectomy (surgery to remove the uterus). Hormone replacement therapy usually in...

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