Format

Send to:

Choose Destination
See comment in PubMed Commons below
FASEB J. 1995 Jul;9(10):926-33.

Differentiation of endothelium.

Author information

  • 1Max-Planck-Institut für physiologische und klinische Forschung, W. G. Kerckhoff Institut, Abteilung Molekulare Zellbiologie, Bad Nauheim, Germany.

Abstract

Vascular endothelial cells cover the entire inner surface of blood vessels in the body. They play an important role in tissue homeostasis, fibrinolysis and coagulation, blood-tissue exchange, vasotonus regulation, the vascularization of normal and neoplastic tissues, and blood cell activation and migration during physiological and pathological processes. It is therefore important to define the basic determinants of the endothelial phenotype and its modulation in response to different signals. Signal recognition, transduction, and processing are likely to be complex events dependent on the status of the target endothelial cell in a given organ or tissue. This status is a consequence of inductive and permissive interactions of a pluripotent cell with soluble and insoluble signaling molecules of the environment during embryonic and postnatal development. This review will focus on the biological mechanisms involved in the differentiation of endothelial cells from the mesoderm and their subsequent functional heterogeneity in different organs and tissues under physiological as well as pathological conditions.

PMID:
7615161
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk