Exp Mycol. 1995 Mar;19(1):1-6.

Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin.

Source

National Institute of Chemistry, Laboratory for Biotechnology and Industrial Mycology, Ljubljana, Slovenia.

Abstract

In the fruiting bodies of the fungus Pleurotus ostreatus, also called the oyster mushroom, we found a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin. The appearance of the inhibitor during the development of fruiting bodies was followed and lovastatin determined in the vegetative mycelium, in the primordia, as well as in different parts of sporocarps of different sizes. Less lovastatin was found in stripes as compared to pili or in mature stages in the lamellae and basidiospores.

PMID:: 7614366; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Comparative Study

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

EBSCO

Molecular Biology Databases

LOVASTATIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Pleurotus fungi produce mevinolin, an inhibitor of HMG CoA reductase. [FEMS Microbiol Lett. 1993]
Pleurotus fungi produce mevinolin, an inhibitor of HMG CoA reductase.
Gunde-Cimerman N, Plemenitas A, Cimerman A. FEMS Microbiol Lett. 1993 Nov 1; 113(3):333-7.
Temporal and spatial expression of ostreolysin during development of the oyster mushroom (Pleurotus ostreatus). [Mycol Res. 2005]
Temporal and spatial expression of ostreolysin during development of the oyster mushroom (Pleurotus ostreatus).
Vidic I, Berne S, Drobne D, Macek P, Frangez R, Turk T, Strus J, Sepcic K. Mycol Res. 2005 Mar; 109(Pt 3):377-82.
Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase. [Biochem Pharmacol. 1993]
Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase.
Cohen LH, van Vliet A, Roodenburg L, Jansen LM, Griffioen M. Biochem Pharmacol. 1993 Jun 9; 45(11):2203-8.
Review Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies. [Biomed Chromatogr. 2006]
Review Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies.
Pasha MK, Muzeeb S, Basha SJ, Shashikumar D, Mullangi R, Srinivas NR. Biomed Chromatogr. 2006 Mar; 20(3):282-93.
Review Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. [Am J Cardiol. 1994]
Review Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Blum CB. Am J Cardiol. 1994 May 26; 73(14):3D-11D.

See reviews... See all...

Cited by 2 PubMed Central articles

Genetic diversity of the edible mushroom Pleurotus sp. by amplified fragment length polymorphism. [Curr Microbiol. 2012]
Genetic diversity of the edible mushroom Pleurotus sp. by amplified fragment length polymorphism.
Pawlik A, Janusz G, Koszerny J, Małek W, Rogalski J. Curr Microbiol. 2012 Oct; 65(4):438-45. Epub 2012 Jul 6.
Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. [Lipids Health Dis. 2004]
Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.
Berger A, Rein D, Kratky E, Monnard I, Hajjaj H, Meirim I, Piguet-Welsch C, Hauser J, Mace K, Niederberger P. Lipids Health Dis. 2004 Feb 18; 3:2. Epub 2004 Feb 18.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-co...
Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin.
Exp Mycol. 1995 Mar ;19(1):1-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: