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Curr Opin Genet Dev. 1995 Apr;5(2):210-6.

Regulation of transcriptional elongation by RNA polymerase II.

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  • 1Imperial Cancer Research Fund, London, UK.


The process of transcription is a cycle of initiation, elongation and termination steps. Initiation and elongation can be rate-limiting for RNA synthesis, and recent evidence shows that transactivators can stimulate both these steps. A stable modification of the RNA polymerase II complex is probably required to convert it from a non-processive to a processive from.

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